在患有严重压力过载过度增大症的患者中,NO供体对LV透气功能的影响
C M Matter1, L Mandinov, P A Kaufmann
1Division of Cardiology, University Hospitals Zurich and Bern, Switzerland.
Circulation
|May 11, 1999
概括
氧化 (NO) 捐赠者通过降低末端透气压力,显著改善了严重压力过载过高症患者的透气功能. 这项研究强调了心脏过度缩.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 生理学 生理学 生理学
背景情况:
- 已知氧化 (NO) 能调节心脏功能,影响心经收缩和心经放松.
- 患有严重压力过载缩和腹功能障碍的患者对NO捐赠者的特定反应仍然没有特征.
研究的目的:
- 调查冠心内氧化 (NO) 捐献者对患有严重压力过载过高和腹功能障碍的患者心脏功能的影响.
主要方法:
- 十七名患有严重大动脉狭窄症的患者接受了冠心内NO捐赠者 (尼甘油或酸).
- 左心室 (LV) 压力和血管图测量在基线和最大NO捐赠剂量后.
- 对NO捐赠者建立了剂量反应曲线.
主要成果:
- 冠内NO捐赠者导致LV末端透气压的显著下降 (从23到14毫米平,-39%).
- 在LV峰值缩压仅略有下降 (从206mmHg降至196mmHg,-4%).
- 末端透析和末端静脉硬度显著降低,而心率,喷射率和填充率保持不变.
结论:
- 在患有严重压力过载缩症的患者中,冠心内NO捐赠者显著降低了LV末端透气压.
- 在这个患者群体中,NO 捐赠者不会损害 LV 缩功能.
- 过度缩小的心肌表现出对NO捐赠者的特别敏感性,从而改善了扩张功能.
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