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大动脉硬度对末期脏疾病生存率的影响
J Blacher1, A P Guerin, B Pannier
1Service de Médecine, Hôpital Broussais, Paris, France.
Circulation
|May 11, 1999
概括
通过大动脉脉冲波速度 (PWV) 测量的大动脉硬度增加,是末期脏疾病 (ESRD) 患者死亡率的强有力的预测指标. 较高的PWV显著增加了所有原因和心血管死亡的风险.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管生物学 血管生物学
背景情况:
- 末期病 (ESRD) 与高心血管发病率和死亡率有关.
- 动脉硬,内心介质厚度和脉压力是ESRD患者的关键动脉变化.
- 大动脉脉冲波速度 (PWV) 对ESRD死亡率的预测值以前没有被研究过.
研究的目的:
- 为了调查是否增加大动脉脉冲波速度 (PWV) 预测终端脏疾病 (ESRD) 患者的全因和心血管死亡率.
主要方法:
- 一组241名接受血液透析的ESRD患者被跟踪平均72个月.
- 在基线时使用多普勒超声波测量了大动脉PWV.
- 考克斯回归分析被用来确定死亡率预测因素,调整因混因素.
主要成果:
- 年龄和大动脉PWV成为所有原因和心血管死亡率的重要预测因素.
- 大动脉PWV增加 (>12.0 m/s vs <9.4 m/s) 与所有原因死亡风险增加5.4倍和心血管死亡风险增加5.9倍有关.
- 在调整后,每次PWV增加1m/s都与39%的全因死亡风险增加有关.
结论:
- 大动脉PWV指出的大动脉硬度增加是ESRD患者全因和心血管死亡率的强有力的独立预测因子.
- 大动脉PWV测量为ESRD患者提供了有价值的预后信息.
- 这些发现强调了评估动脉硬性在ESRD中控制心血管风险的重要性.
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