聚合体:由双块共聚合物制成的坚硬囊泡
B M Discher1, Y Y Won, D S Ege
1School of Engineering and Applied Science, and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
概括
与天然脂质膜相比,由块共聚合物制成的巨型聚合体具有更高的性和降低的水透性. 这些合成囊泡提供了一个有前途的新类薄囊.
科学领域:
- 材料科学 材料科学 材料科学
- 生物物理学的生物物理.
- 聚合物化学 聚合物化学
背景情况:
- 自然的细胞膜是由脂组成的.
- 脂质双层是生物囊泡和脂质体的基础.
- 了解合成替代脂质双层对于仿生应用至关重要.
研究的目的:
- 为了合成和表征基于聚合物的囊泡 (聚合体),使用两性双块共聚合物.
- 为了比较聚合体的机械和透性特性与天然的脂质膜.
- 探索聚合体作为合成囊的潜力.
主要方法:
- 两性双块共聚合物 (聚乙烯氧化物-聚乙烯,EO40-EE37) 用于形成囊泡.
- 微操纵技术用于囊泡的特征.
- 测量了机械性能 (曲和面积膨胀模块) 和水的透性.
主要成果:
- 聚合体表现出与脂质膜相比的膜曲和面积扩张模块.
- 巨型聚合体在破裂前表现出明显更高的性和更大的区域应变耐受性.
- 与脂双层相比,聚合体膜的水透性至少减少了10倍.
结论:
- 基于区块共聚合物的聚合体体代表了一类新的强大的合成囊泡.
- 这些聚合体具有增强的机械强度和降低的透性,在关键方面超过自然脂质膜.
- 聚合体为开发先进的合成薄囊提供了一个有前途的平台.
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