相关实验视频

Updated: Jul 20, 2026

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

需要RAFT1与gephyrin的相互作用,用于对拉巴胺素敏感的信号传输

D M Sabatini1, R K Barrow, S Blackshaw

  • 1The Johns Hopkins University School of Medicine, Department of Neuroscience, 725 North Wolfe Street, Baltimore, MD 21205, USA.

Science (New York, N.Y.)
|May 15, 1999
PubMed
概括

哺乳动物的目标拉巴胺素 (mTOR) 蛋白与神经元甘氨酸受体集群中的关键组成部分基菲林相互作用. 这种相互作用对于mTOR信号通路至关重要,包括那些调节蛋白质合成的信号通路.

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G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay

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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

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Small GTPases - Ras and Rho

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Activation and Inactivation of G Proteins

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Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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