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A Mouse Model of in Utero Transplantation
Published on: January 27, 2011
通过细胞内精子注射受孕的儿童在1岁时的医疗和发育结果
J R Bowen1, F L Gibson, G I Leslie
1Department of Neonatology, Royal North Shore Hospital, Sydney, Australia.
Lancet (London, England)
|May 18, 1999
概括
通过细胞体内精子注射 (ICSI) 怀孕的儿童没有出现严重健康问题的风险增加,但在一年内发育迟缓的发病率较高. 建议对这些儿童进行进一步的随访.
科学领域:
- 生殖医学 生殖医学
- 发育儿科 发育儿科
- 遗传学 遗传学 是一个
背景情况:
- 内细胞质精子注射 (ICSI) 是男性严重不孕症的主要治疗方法.
- 关于使用ICSI怀孕的儿童的长期结果的数据有限.
- 这项研究评估了一岁的ICSI受孕儿童的医疗和发育状况.
研究的目的:
- 评估1岁时通过ICSI怀孕的儿童的医疗和发育结果.
- 将这些结果与通过常规体外受精 (IVF) 和自然受精怀孕的孩子进行比较.
主要方法:
- 一项前性研究,将89名ICSI受孕儿童与84名试管婴儿和80名自然受孕儿童进行比较.
- 使用贝利婴儿发育尺度 (第二版) 进行发育评估.
- 计算所有参与者的心理发展指数 (MDI).
主要成果:
- 在第一年,主要的先天性形或健康问题没有显著差异.
- 与试管婴儿和自然受孕儿童相比,ICSI受孕儿童的MDI平均值明显较低 (95.9比101.8和102.5).
- 17%的ICSI孕育的孩子表现出发育延迟 (MDI<85),而IVF则为2%和1% (自然).
结论:
- 大多数ICSI怀孕的孩子都很健康,发育正常.
- 在通过ICSI怀孕的儿童中,在一年内出现轻度发育迟缓的风险较高.
- 持续的发育监测对于ICSI怀孕的儿童至关重要,以确定潜在的长期智力或学习困难.
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