在人类血管光滑肌肉中,不同的雌激素和孕受体信息
Y K Hodges1, J K Richer, K B Horwitz
1Department of Medicine, Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colo. 80262, USA.
Circulation
|May 25, 1999
概括
变异性雌激素和孕激素受体在人类血管光滑肌肉中发现. 这些变异可能解释了性激素如何在各种组织中不同影响血管.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 血管生物学 血管生物学
背景情况:
- 雌激素促进乳腺/子宫细胞生长,但保护血管光滑肌肉.
- 激素作用的变化可能源于特定组织的受体表达.
- 这项研究研究了人体血管光滑肌肉中的雌激素受体 (ERs) 和孕激素受体 (PRs).
研究的目的:
- 分析人体血管光滑肌肉中ERs和PRs的结构.
- 为了确定这些受体的潜在变异形式.
- 了解受体变异对血管组织中性激素影响的影响.
主要方法:
- 从人类血管光滑肌肉中分离RNA.
- 使用逆转录酶和聚合酶连锁反应对ER-alpha和PR功能域的表征.
- 关于PR变种的功能性特征.
主要成果:
- 确定了野生型ER-alpha和PR,以及5种ER-alpha变体和2种PR变体的转录.
- 变体转录中出现了激素结合域中的缺失 (例如,PRDelta4,PRDelta6,ERDelta4,ERDelta5,ERDelta6,ERDelta7,ERDelta6,7).
- PRDelta6作为野生型受体的主导负抑制剂;PR变体在绝经前但不是绝经后的妇女中被发现.
结论:
- 变体ER和PR转录在人类血管光滑肌肉中得到广泛表达.
- 异质受体形式可能会调解复杂的,组织特异性的性激素效应.
- 变种ER和PR的存在可能会改变雌激素和孕激素在血管光滑肌肉中的生理影响.
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