可卡因引发心肌梗塞的诱因 可卡因引发心肌梗塞的诱因
M A Mittleman1, D Mintzer, M Maclure
1Institute for Prevention of Cardiovascular Disease, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. mmittlem@hsph.harvard.edu
Circulation
|June 3, 1999
概括
可卡因使用显著增加了急性心肌梗塞 (心脏病发作) 的直接风险的23.7倍. 这种风险很大,但是短暂的,突出的是可卡因.
科学领域:
- 心脏病学 心脏病学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 可卡因是已知的急性心肌梗塞 (AMI) 的触发因素,即使在没有先前冠状动脉疾病的个体中也是如此.
- 在使用可卡因后,AMI的直接风险增加的确切程度尚未得到充分确立.
研究的目的:
- 量化与可卡因使用相关的急性心肌梗塞 (AMI) 的直接风险.
- 调查使用可卡因并经历AMI的个体的特征.
主要方法:
- 采用了病例交叉研究设计,采访了3946名AMI患者.
- 参与者报告说,在症状出现前一小时内使用了可卡因.
- 自相匹配的对照数据比较了AMI发病前可卡因使用频率与预期频率.
主要成果:
- 在3946名患者中,有9名患者 (1%) 报告在AMI发作60分钟内使用可卡因.
- 可卡因使用者更有可能是年轻人,男性,当前吸烟者和少数群体.
- 可卡因使用与60分钟内发生AMI的风险增加了23.7倍 (95%CI为8.5至66.3).
结论:
- 可卡因使用导致AMI风险大幅,突然和暂时增加,特别是在风险较低的人群中.
- 研究可卡因的病理生理影响可能会阐明由其他压力因素引发的AMI机制.
相关概念视频
Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Introduction Cardiac Emergencies
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
Cardiomyopathy I: Introduction and Classification
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...


