鼠标行为的遗传学:与实验室环境的相互作用
J C Crabbe1, D Wahlsten, B C Dudek
1Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA. crabbe@ohsu.edu
Science (New York, N.Y.)
|June 5, 1999
概括
实验室环境显著影响神经行为遗传学研究. 实验室之间的标准化测试揭示了系统差异,表明结果可能是实验室特定的,特别是对于突变特征.
科学领域:
- 神经行为遗传学 神经行为遗传学
- 实验室动物科学 动物科学
- 行为表现型化行为表现型化.
背景情况:
- 杂交的小鼠菌株是神经行为遗传学研究的关键模型.
- 实验室环境因素可能会混行为研究.
- 了解环境影响是可靠基因研究的关键.
研究的目的:
- 研究实验室环境对小鼠行为表型的影响.
- 评估实验室间变异对行为遗传学研究的影响.
- 为了确定基因差异是否在不同的测试环境中一致.
主要方法:
- 同时测试多个内生小鼠菌株和一个无基因突变物.
- 使用了六个行为测试的标准化电池.
- 在三个不同的实验室中等同设备,测试协议和环境变量.
主要成果:
- 在所有测试行为中观察到显著的菌株特异性差异.
- 尽管进行了严格的标准化,但在实验室中发现了系统的行为差异.
- 观察到的遗传效应的幅度因特定行为特定测试实验室而异.
结论:
- 实验室环境在小鼠行为研究中引入了系统的变化.
- 标准化努力可能无法完全消除行为结果的实验室间差异.
- 突变特征研究的结果可能与它们进行的特定实验室具有特异性.
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