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相关概念视频

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

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相关实验视频

Updated: Jul 6, 2026

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung
07:10

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

Published on: May 20, 2019

在轻度和中度慢性阻塞性肺病中吸入布德索尼德的长期影响:一项随机对照试验.

J Vestbo1, T Sørensen, P Lange

  • 1Department of Respiratory Medicine, Hvidovre Hospital, Denmark. jvestbo@inet.uni2.dk

Lancet (London, England)
|June 8, 1999
PubMed
概括

吸入布德索尼德在慢性阻塞性肺病 (COPD) 患者中没有显示出临床益处. 长期吸入的皮质类固醇可能对轻度至中度的COPD没有好处.

科学领域:

  • 肺部病理学 肺部病理学
  • 药理学 药理学是指药理学的学科.
  • 临床试验 临床试验

背景情况:

  • 在COPD中吸入性皮质类固醇 (ICS) 的长期疗效尚不清楚.
  • 这项研究研究了布德索尼德对肺功能下降和COPD患者症状的三年影响.

研究的目的:

  • 为了评估慢性阻塞性肺病 (COPD) 患者吸入布德索尼德的长期疗效.
  • 在3年的时间内评估布德索尼德对肺功能下降和呼吸系统症状的影响.

主要方法:

  • 一项为期3年的随机,双盲,安慰剂对照研究.
  • 290名COPD患者接受了布塞尼德或安慰剂.
  • 主要结局是1秒内强迫呼气体积 (FEV1) 降低的速度.

主要成果:

  • 在布德塞尼德 (46.0毫升/年) 和安慰剂 (49.1毫升/年) 组之间,FEV1下降率没有显著差异.
  • 吸入布德索尼德并没有改善呼吸道症状.
  • 治疗耐受性很好,在恶化方面没有显著差异.

结论:

  • 吸入布德索尼德在通过一般人群查发现的COPD患者中没有提供临床益处.

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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis
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A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis

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Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung
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Published on: May 20, 2019

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A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis
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A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis

Published on: January 16, 2026

  • 长期吸入皮质类固醇在治疗轻度至中度的COPD中的作用受到质疑.