从Thermotoga maritima的基因组序列中获得的证据证明了Archaea和细菌之间的横向基因转移
K E Nelson1, R A Clayton, S R Gill
1Institute for Genomic Research, Rockville, Maryland 20850, USA.
Nature
|June 9, 1999
概括
瑟莫托加海上MSB8的基因组显示了广泛的糖降解途径和高比例的古人类类基因. 基因聚类表明热友性Eubacteria和Archaea之间潜在的横向基因转移.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 进化生物学 进化生物学
背景情况:
- 对Thermotoga maritima MSB8的基因组进行了测序,以了解其代谢能力和进化关系.
- 了解热友生物的遗传构成,可以了解生命如何适应极端环境.
研究的目的:
- 分析Thermotoga maritima MSB8的基因组,确定编码区域,代谢途径和具有考古起源的基因.
- 为了调查热友性Eubacteria和Archaea之间横向基因转移的证据.
主要方法:
- 全基因组测序和分析Thermotoga海上MSB8.8. 的
- 比较基因组学用于识别正系基因并评估基因与其他生物体的相似性,特别是古生物.
- 基因聚类和基因顺序的保存的分析.
主要成果:
- 这1,860,725个基对的基因组包含1,877个预测的编码区域,54%具有已知的功能,46%具有未知的功能.
- 确定了许多糖和植物多糖分的降解途径.
- 发现了108个基因与独家在热友的Eubacteria和Archaea中的ortologues,T. maritima的基因中有24%的基因显示了古老的相似性.
结论:
- 瑟莫托加海事表现出独特的遗传组成,具有显著的考古影响.
- 考古类基因的聚类和保存的基因顺序表明热友性Eubacteria和Archaea之间存在大量的横向基因转移事件.
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