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Updated: Jul 5, 2026

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
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Published on: November 1, 2011

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在体变化之前和之后,小鼠免疫球蛋白轻链基因的序列

O Bernard, N Hozumi, S Tonegawa

    Cell
    |December 1, 1978
    PubMed
    概括

    研究人员对小鼠免疫球蛋白兰巴达轻链基因进行了测序,揭示了一个完整的基因是通过变量 (V) 和连接 (J) DNA片段之间的体质重组形成的. 这一过程产生了功能性抗体基因,在重组部位没有序列同质性.

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