心房动对人类心房收缩功能的短期影响
E G Daoud1, P Marcovitz, B P Knight
1Division of Cardiology, Department of Internal Medicine, University of Michigan Hospital, Ann Arbor, Michigan, USA.
Circulation
|June 15, 1999
概括
在心转动后,一段短暂的心房动 (AF) 可能会损害左心房尾 (LAA) 功能. 维拉帕米尔治疗可以减轻这种AF诱导的收缩功能障碍.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 心脏生理学 心脏生理学
背景情况:
- 心房动 (AF) 的转化与心房麻木有关.
- 短暂的AF发作对左心房附属体 (LAA) 排空速度的直接影响尚不清楚.
研究的目的:
- 评估短暂的AF发作是否会影响左心脏功能.
- 为了确定维拉帕米尔是否可以改变AF对左心脏功能的影响.
主要方法:
- 经食道心声学测量了在19名接受电生理学手术的患者中LAA排空速度.
- AF是通过快速右心房节奏大约15分钟诱导的.
- 韦拉帕米尔预治疗给了一小部分患者.
主要成果:
- 在AF心脏转变后,LAA排空速度显著下降 (P=0.02),但在3分钟内恢复.
- 在AF后观察到排空速度平均减少9.7%.
- 韦拉帕米尔的预治疗预防了AF后显著的排空速度减少 (P=0.08).
结论:
- 即使是短暂的AF发作也可能导致心转动后的暂时心房收缩功能障碍.
- 这种功能障碍似乎对维拉帕米尔敏感,并可能由介导.
- 心房功能的快速恢复表明这是一个短暂的机制.
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