在结核病治疗后,血清IgE总量下降
J F Adams1, E H Schölvinck, R P Gie
1Centre for Molecular and Cellular Biology and Department of Medical Biochemistry, University of Stellenbosch Medical School, Tygerberg, South Africa.
Lancet (London, England)
|June 22, 1999
概括
结核病感染不会阻止强烈的免疫球蛋白E (IgE) 反应. 成功治疗结核病会降低IgE水平,这表明免疫应答的调节.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 过敏研究 研究过敏
背景情况:
- 结核菌菌的感染会引发1型免疫反应.
- 肠道寄生虫诱导2型免疫反应.
- 已知1型和2型免疫反应相互抑制.
研究的目的:
- 调查Mycobacterium结核菌感染是否会降低血清IgE的调节.
- 为了确定结核病和IgE水平之间的关系.
主要方法:
- 在南非进行的前性研究,对37名对照组和33名青少年结核病患者进行了研究.
- 测量了总血清IgE,阿斯卡里斯特异性IgE和过敏原特异性IgE.
- 进行曼图克斯皮肤测试以评估细胞介导免疫力.
主要成果:
- 在治疗前,结核病患者的总IgE比对照患者高.
- 在成功治疗结核病后,IgE水平显著下降.
- 在治疗前,阿斯卡里斯特异性IgE在患者中升高,治疗后降低.
- 结核素强化与患者的IgE水平呈反相关性.
结论:
- 结核菌菌菌感染与显著的IgE反应相容.
- 成功治疗结核病导致IgE的下调.
- 这种下调可能是由于增强了1型免疫反应.
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