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甲状腺功能障碍的放射性治疗后的癌症发病率和死亡率:基于人口的队列研究
J A Franklyn1, P Maisonneuve, M Sheppard
1Department of Medicine, University of Birmingham, UK.
Lancet (London, England)
|June 26, 1999
概括
放射性治疗甲状腺功能障碍症通常是安全的,显示总体癌症发病率和死亡率下降. 然而,由于小肠和甲状腺癌的风险增加,需要长期保持警.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 放射性是甲状腺功能障碍的常见一线治疗方法.
- 人们对潜在的癌症风险增加存在担忧,特别是在年轻患者中.
研究的目的:
- 为了研究为甲状腺功能障碍治疗放射性治疗的患者的癌症发病率和死亡率.
- 评估放射性治疗对癌症发展的长期安全性.
主要方法:
- 在1950年至1991年期间在英国伯明翰接受治疗的7417名患者的基于人口的研究.
- 癌症诊断和死亡与英格兰和威尔士的国家数据的比较,根据年龄,性别和时间段进行调整.
主要成果:
- 总体癌症发病率和死亡率有所降低 (SIR 0.83,SMR 0.90).
- 小肠和甲状腺癌的发病率和死亡率显著增加,尽管绝对风险仍然很低.
- 胰腺,支气管,气管,膀和淋巴/血液系统的癌症的发病率下降.
结论:
- 甲状腺功能障碍的放射性治疗与整体癌症风险的放心有关.
- 由于小肠和甲状腺癌的相对风险较高,建议进行长期监测.
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