亚酸与血液中水平的关系
1Department of Epidemiology and Biostatistics, University of California, Veterans Affairs Medical Center, San Francisco 94121, USA. jasimon@itsa.ucsf.edu
JAMA
|July 1, 1999
概括
高血清 Askorbic 酸水平与儿童和成人血液中较低的水平有关. 这表明维生素C可能在降低毒性风险方面发挥作用.
科学领域:
- 环境健康 环境健康
- 营养科学 营养科学
- 毒理学 毒理学 毒理学
背景情况:
- 动物研究表明,酸 (维生素C) 合物,降低毒性.
- 人类对酸对毒性的影响的研究仍然没有确定性.
研究的目的:
- 在美国人口样本中调查血清 Askorbic 酸水平与血液中含量升高之间的关联.
主要方法:
- 对NHANES数据 (1988-1994) 的横截面分析,包括4213名青少年和15365名成年人.
- 测量了血清中 Askorbic 酸和血水平.
- 根据人口统计和饮食因素进行调整.
主要成果:
- 血清中酸三位数较高与青少年 (89%的减少) 和成年人 (65-68%的减少) 血中含量升高的患病率显著降低有关.
- 血清 Askorbic 酸与成人血中较低的含量独立相关,但与青少年无关.
- P-趋势值表明了显著的关联 (P=.002对于年轻人,P=.03对于成年人).
结论:
- 血清中高酸水平独立地与高血水平的患病率较低有关.
- 研究结果表明,阿斯科布酸在控制毒性方面可能起到公共卫生作用.
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