长时间的心房动引起的电生理学变化是可逆的吗? :使用心房除器进行观察
L M Rodriguez1, C Timmermans, H J Wellens
1Department of Cardiology, Academic Hospital, Maastricht, The Netherlands. L.M.Rodriguez@cardio.azm.nl
Circulation
|July 14, 1999
概括
在大多数有长期AF病史的患者中,心房动 (AF) 在延长鼻节律后仍然可诱导. 耳前电生理学没有正常化,表明即使在成功治疗后也会持续存在变化.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 心脏节律失常症 心脏节律失常症
背景情况:
- 动物研究表明,长时间的心房动 (AF) 会改变心房有效耐火期 (AERP).
- 长期AF对人类心房电生理学的影响需要进一步研究.
研究的目的:
- 在使用Metrix Atrioverter治疗的长期,复发性AF患者中,在延长鼻节律后评估心房电生理学.
- 分析迅速心脏转变对AF复发和鼻节律持续时间的影响.
主要方法:
- 在四名患有复发性AF (3-21年持续) 的患者进行了电生理学研究,这些患者在Atrioverter植入后.
- 在植入前和>1000小时的鼻节律之后测量了心房有效耐火期 (AERP).
- 用单个心房过早跳动来评估心房 (AF) 的诱导性.
主要成果:
- 在长时间的鼻节律 (>1000小时) 后,在4名患者中的3名患者中,AF仍然可以通过单个心房早跳来诱导.
- 在一个患者中,AF不是可诱导的,AERP测量与植入前值相似.
- 在有长期复发性AF史的患者中,没有观察到心房电生理学的正常化.
结论:
- 长期的复发性AF导致心房持续的电生理变化.
- 即使经过长时间的鼻节律和成功的AF治疗,心房电生理学也不能完全恢复到正常模式.
- 一次过早的心跳导致AF的诱导性在大多数患有长期AF病史的患者中仍然存在.
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