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Updated: Jun 30, 2026

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
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Published on: January 3, 2012

被Plasmodium falciparum感染的红细胞调节树突细胞的成熟

B C Urban1, D J Ferguson, A Pain

  • 1Institute of Molecular Medicine, Oxford Centre, John Radcliffe Hospital, Headington, UK.

Nature
|July 14, 1999
PubMed
概括

疟疾寄生虫 (Plasmodium falciparum) 感染并附着在树突细胞上,阻碍它们的成熟. 这损害了T细胞的反应,揭示了疟疾的新免疫逃避策略.

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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...