人类乳头瘤病毒状态与宫病变的关系以及宫癌查的后果:一项前性研究
M A Nobbenhuis1, J M Walboomers, T J Helmerhorst
1Department of Obstetrics and Gynaecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Lancet (London, England)
|July 16, 1999
概括
持续高风险的人类乳头瘤病毒感染对于3级宫内皮质瘤 (CIN3) 是必要的. HPV检测有助于管理患有硬化症的妇女,指导宫癌查的转诊决策.
科学领域:
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 高风险的人类乳头瘤病毒 (HPV) 感染与子宫癌的发展有关.
- 这项研究调查了HPV测试在宫癌查方案中的有用性.
研究的目的:
- 评估HPV检测在治疗宫硬化症妇女中的作用.
- 确定持续高风险HPV感染与3级宫内皮质瘤 (CIN3) 之间的关联.
主要方法:
- 353名患有轻度至重度硬化症的妇女使用细胞学,肠镜检查和高风险HPV检测进行了监测.
- 随访包括大肠镜检查,活检和HPV检测,平均时间为33个月.
- 临床进展,定义为CIN 3或怀疑宫癌,是主要终点.
主要成果:
- 33名妇女经历了临床进展,所有人都患有持续的高风险HPV感染.
- 临床进展的累积6年发生率为40%.
- 在6个月的第二次HPV测试更好地预测了CIN 3,而不是重复的宫涂抹在轻度至中度硬化症的妇女.
结论:
- 持续的高风险HPV感染对于CIN 3的发展和维持是必要的.
- 患有严重硬化症的妇女需要立即转诊妇科医生.
- 患有轻度至中度硬化症的妇女在6个月后第二次阳性HPV测试后受益于转诊.
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