Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

[Fibroepithelial tumours of the breast: not always a simple fibroadenoma].

Nederlands tijdschrift voor geneeskunde·2017
Same author

Pre-B-Cell Acute Lymphoblastic Leukemia in Childhood.

Leukemia & lymphoma·2016
Same author

Burden of spousal caregivers of stage II and III esophageal cancer survivors 3 years after treatment with curative intent.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2015
Same author

A revised definition for cure of childhood acute lymphoblastic leukemia.

Leukemia·2014
Same author

Successful challenges using native E. coli asparaginase after hypersensitivity reactions to PEGylated E. coli asparaginase.

Cancer chemotherapy and pharmacology·2014
Same author

Calcium and cholecalciferol supplementation provides no added benefit to nutritional counseling to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia (ALL).

Pediatric blood & cancer·2014

相关实验视频

Updated: Jul 14, 2026

Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

在放射治疗和抗代谢剂后,二次脑瘤的发病率很高.

M V Relling1, J E Rubnitz, G K Rivera

  • 1Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

Lancet (London, England)
|July 16, 1999
PubMed
概括

治疗急性淋巴细胞白血病的儿童,用头骨放射疗法和强化抗代谢剂疗法治疗,脑瘤的发病率很高. 遗传因素和治疗强度可能会增加这些与辐射相关的大脑瘤的风险.

更多相关视频

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

相关实验视频

Last Updated: Jul 14, 2026

Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

科学领域:

  • 儿科瘤学 儿科瘤学
  • 辐射瘤学 辐射瘤学
  • 癌症遗传学 癌症遗传学

背景情况:

  • 大脑瘤在儿童急性淋巴细胞白血病幸存者中很罕见.
  • 在接受全疗法研究XII协议的儿童中观察到脑瘤的频率升高.

研究的目的:

  • 调查脑瘤发病率增加的原因,在儿童治疗骨放射治疗.
  • 在这个队列中确定与辐射诱导的大脑瘤相关的危险因素.

主要方法:

  • 评估了52名接受预防性头骨放射治疗的儿童的临床,生物学和药理动力学数据.
  • 亚组之间的脑瘤发病率与历史对照的比较.
  • 分析了 thiopurine 代谢和 thiopurine 核酸代谢物水平中的遗传缺陷.

主要成果:

  • 52名被照射的儿童中有6名 (12.8%) 患有脑瘤,这一发病率明显高于未被照射的患者或其他方案的患者.
  • 四名儿童的硫氨酸核酸代谢物水平较高;三名儿童在硫氨酸代谢过程中存在遗传缺陷.
  • 脑瘤的8年累计发病率在患有缺陷氨酸甲基转移酶表型 (42.9%) 与野生型 (8.3%) 的儿童中显著高.

结论:

  • 针对急性淋巴细胞白血病的预防性放射治疗应仅限于中枢神经系统复发的高风险患者.
  • 遗传倾向和强化抗代谢物治疗可能会增加与辐射相关的大脑瘤的风险.