自发神经元活动的相关结构 in vivo 在正在发展的横向生殖细胞核中
1Howard Hughes Medical Institute and Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. weliky@cvs.rochester.edu
概括
发展中的视觉通路中的自发活动塑造了视网膜输入. 在眼睛打开之前,皮质 - thalamic反对于侧面生殖细胞核 (LGN) 的相关活动至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 视觉系统研究 视觉系统研究
背景情况:
- 在视网膜以外的视觉系统中,自发神经活动的功能性质在很大程度上仍然未被描述.
- 了解早期视觉通路的发展对于识别关键时期和潜在干预措施至关重要.
研究的目的:
- 调查眼睛开放前在发展中侧面生殖细胞核 (LGN) 中自发活动的特征和起源.
- 阐明视网膜输入和皮质 - thalamic反在塑造LGN自发活动模式中的作用.
主要方法:
- 利用LGN中的多电极记录,在眼睛打开前的时间内,在醒着的,表现出色的雪身上.
- 操纵了视网膜输入和皮质 - thalamic反通路,以评估它们对LGN活性的影响.
主要成果:
- 在LGN中观察到自发活动模式,表明视网膜驱动在较高视觉中心的转变.
- 发现LGN活动中显著的双眼相关性取决于完整的皮质 - thalamic反.
- 证明皮质 - thalamic反维持LGN爆发活动,即使没有视网膜输入.
- 与ipsilateral眼睛活动相比, contralateral眼睛活动对thalamic活动的影响更强.
结论:
- 在体内,LGN自发活动的模式源于视网膜,丘脑和皮质之间的复杂相互作用.
- 皮层 - thalamic反在组织视觉 thalamus 发育中的自发活动中起着至关重要的作用.
- 发育中的视觉系统表现出复杂的活动调制,甚至在通过眼睛打开的感觉体验之前.
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