在猪中进行心房线性切除. 对心房电生理学和病理学的慢性影响
1Cardiovascular System Laboratory, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. mdlior@tx.technion.ac.il
Circulation
|July 27, 1999
概括
连续的射频 (RF) 应用会造成长时间的连续线性心房损伤. 这些病变是外壁病变,表现出导电阻塞,表明心律失常的心房除成功.
科学领域:
- 电子生理学 电子生理学
- 心脏外科手术 心脏外科手术
- 医疗器械 医疗器械
背景情况:
- 越来越需要长期,连续的线性废除在心房失常症.
- 部署和评估这些病变的挑战.
- 关于对心房电生理学和病理学的短期和长期影响的有限数据.
研究的目的:
- 评估使用顺序射频 (RF) 应用创造长线性心房病变的可行性和有效性.
- 评估这些病变对心房电生理学的连续性,转移性和长期影响.
主要方法:
- 利用非光镜绘图和导航技术在8只猪身上创建3D电解剖图.
- 交付了连续的射频应用,增加功率到80%的单极电图振幅减少.
- 评估损伤连续性使用激活地图,双电位和双极电图幅度在4周后的剥离.
主要成果:
- 在所有动物中成功地产生了上下 venae cavae之间的连续和横向线性病变.
- 通过证明导电阻,显著的激活时间差异和相反的激活波面方向来确认损伤连续性.
- 尸体解剖显示连续的,平均50.5毫米的穿刺性病变,具有穿刺性纤维化组织学证据.
结论:
- 由单极振幅减弱指导的连续射频应用,有效地产生长期连续和横向线性心房损伤.
- 损伤连续性可靠地通过3D激活地图上的导电块,双电位和低电图幅度来表示.
相关概念视频
Mechanism of Cardiac Arrhythmias
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Layers of the Heart Wall
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
Disturbances in Heart Rhythm
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...


