左心房放松和左心室缩功能决定了左心房储功能
P Barbier1, S B Solomon, N B Schiller
1Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, USA.
Circulation
|July 27, 1999
概括
左心房储功能有两个阶段,受心房收缩,放松和左心室底下降的影响. 急性缺血会增加硬度,并损害水库功能.
科学领域:
- 心血管生理学心血管生理学
- 心脏机械学 心脏机械学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 左心房 (LA) 储库功能的决定因素及其对左心室 (LV) 功能的影响仍然不完全理解.
- 量化这些关系对于理解心脏表现至关重要.
研究的目的:
- 量化LA储功能的决定因素及其对LV功能的影响.
- 调查急性LV区域性缺血对LA水库功能和机制的影响.
主要方法:
- 采用了一个开放心周猪模型,诱导LV区域性缺血症.
- 使用高保真压力记录 (LV,LA,RV) 和2D心声回声仪进行LA区域评估.
- 计算了LA压力区域循环,多普勒传导流,LV tau,LA放松和LA刚度.
主要成果:
- 确定了两个不同的LA储阶段:早期 (取决于LA喷射速率和放松) 和晚期 (取决于LV基下降).
- 急性LV缺血显著减少LA储面积变化和增加LA度.
- 填充LA储是心脏输出最强的预测因素.
结论:
- LA储功能包括由心房动态和LV基运动影响的早期和晚期阶段.
- 急性LV区域性缺血通过增加LA硬度和减少LV基下降而对LA储功能产生不利影响.
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