血清素与冠状动脉疾病和心脏事件有关
K Vikenes1, M Farstad, J E Nordrehaug
1Departments of Heart Disease and Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.
Circulation
|August 3, 1999
概括
高血清水平与男性冠状动脉疾病 (CAD) 有关. 这种联系在年轻人中特别强烈,即使考虑到心脏病的传统风险因素,这种联系仍然存在.
科学领域:
- 心血管医学 心血管医学
- 生物化学 生物化学
- 医学研究 医学研究
背景情况:
- 血小板在冠状动脉动脉生成中起作用.
- 血小板分泌的血清素 (5-hydroxytryptamine) 影响血管壁,促进血栓生成,配基生成和光滑肌肉细胞的增殖.
- 血清素是冠状动脉疾病 (CAD) 发展的潜在因素.
研究的目的:
- 评估血清激素水平与CAD之间的关联.
- 在传统的风险因素中评估血清素作为CAD的预测因子.
- 为了研究血清素和心脏事件之间的关系.
主要方法:
- 分析了121名接受冠状动脉血管造影的男性患者.
- 测量了血清激素,血小板数和传统的CAD风险因素.
- 统计分析,包括赔率比率和置信区间,用于确定关联.
主要成果:
- 高血清素水平 (切割点1000nmol/L) 与CAD显著相关 (OR 3.4).
- 还发现吸烟,高胆固醇,高血小板计数和家族病史的相关性.
- 在调整了常规风险因素后,高血清仍然与CAD相关 (OR 3.8).
- 这种关联在70岁以下的患者中更为强烈,在这些患者中,高血清激素也预测了随访期间的心脏事件.
结论:
- 血清素与冠状动脉疾病有关.
- 血清素与心脏事件的发生有关,特别是在年轻的患者中.
- 在调整了常规风险因素后,血清激素和CAD之间的关联仍然存在.
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