对于阻塞性尿路病的产前干预后儿童的长期结果
A L Freedman1, M P Johnson, C A Smith
1Department of Paediatric Urology, Children's Hospital of Michigan, Detroit, USA.
Lancet (London, England)
|August 7, 1999
概括
对胎儿阻塞性尿路病的产前干预显示出有希望的长期结果. 囊腔带分流的安置可以改善严重病例的结果,提供与不那么严重的疾病相比的结果.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 胎儿外科手术 胎儿外科
- 新生儿护理 新生儿护理
背景情况:
- 对于胎儿阻塞性尿路病的产前干预已经进行了十多年.
- 胎儿干预后的长期结果在很大程度上是未知的.
- 评估胎儿干预的长期影响对于指导临床实践至关重要.
研究的目的:
- 为了评估那些接受了胎儿阻塞性尿路病的膀膜静脉分流安置的儿童的长期结果.
- 了解产前干预对生长,功能和体的影响.
主要方法:
- 对14名接受了囊膜静脉突变装置安置的儿童的临床结果的回顾性审查.
- 对活过2岁以上的儿童进行后续评估.
- 对诊断,生长参数,功能和尿失禁的分析.
主要成果:
- 在34名接受了分离器安置的患者中,有21人活了超过2年. 平均随访时间为54.3个月.
- 常见的诊断包括腹综合征 (7) 和后尿道 (4).
- 重要发现包括身高矮 (86%低于25百分位),功能衰竭/移植 (36%),功能衰竭 (21%) 和不同程度的尿失禁 (50%大陆).
结论:
- 通过囊泡膜突变的产前干预可能有利于患有严重阻塞性尿路病的胎儿,可能避免致命的新生儿过程.
- 取得的结果与通常在产后诊断的不那么严重的病例相美.
- 这种干预提供了一种可行的选择,用于改善被选中的胎儿阻塞性尿路病例的长期结果.
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