人类胎儿心脏中的内皮生长因子受体
T A Partanen1, T Makinen, J Arola
1Molecular/Cancer Biology Laboratory, Department of Pathology, Haartman Institute, University of Helsinki, Finland.
Circulation
|August 10, 1999
概括
研究人员绘制了人类心脏内皮生长因子受体表达的地图. 这项研究详细介绍了内心,冠状动脉和毛细血管中的受体模式,有助于心血管研究.
科学领域:
- 心血管生物学 心血管生物学
- 分子生物学分子生物学
- 免疫组织化学 免疫组织化学
背景情况:
- 内皮受体氨酸激酶,包括血管内皮生长因子受体 (VEGFR) 和血管蛋白质受体 (Tie),对于血管发育至关重要.
- 神经素-1 (NP-1) 也与VEGF相互作用.
- 虽然它们在血管生成和血管生成中的作用已在小鼠中确立,但它们在人类血管系统中的特定表达在很大程度上仍未被描述.
研究的目的:
- 在不同类型的人类心血管中研究VEGFR,Tie和NP-1的精确表达模式.
- 为提供这些受体在人类心脏血管系统中的定位的详细地图.
主要方法:
- 冰的人类胎儿心脏部分的免疫组织化学染色.
- 使用特定受体单克隆和多克隆抗体用于VEGFR-1,VEGFR-2,VEGFR-3,Tie-1,Tie-2和NP-1检测.
主要成果:
- 在各种心脏结构中观察到的差异表达.
- 内心表达的VEGFR-1,VEGFR-2,NP-1,Tie-1和Tie-2均为内心表达的VEGFR-1,VEGFR-2,NP-1,Tie-1和Tie-2.
- 冠状动脉血管对Tie-1,Tie-2,VEGFR-1和NP-1呈阳性.
- 心肌毛细血管和心上血管被染色为VEGFR-1,VEGFR-2,NP-1和Tie-1.
结论:
- 这项研究揭示了人类心血管中内皮生长因子受体的独特表达特征.
- 这些详细的表达数据对于理解心脏生理学和病理学的受体功能是有价值的.
- 这些发现支持心血管医学中的潜在诊断和治疗应用.
相关概念视频
Adult Stem Cells
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Anatomy of the Intestines
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Zygotic Development And Stem Cell Formation
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Embryonic Connective Tissues
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...


