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Formation of Biomembrane Microarrays with a Squeegee-based Assembly Method
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布朗的子:脂质双层中的分子分离,以图案阵列为支
1Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
概括
研究人员开发了一种新的几何布朗式子来分离分子. 该装置使用不对称的屏障和电场来指导粒子运动,从而实现分子选.
科学领域:
- 物理化学 物理化学
- 材料科学 材料科学 材料科学
- 生物物理学的生物物理.
背景情况:
- 布朗的子利用时间变化的不对称潜力进行粒子分离.
- 现有的布朗式杆是有效的,但可能是复杂的实施.
- 扩散颗粒的分离在各种科学和工业应用中至关重要.
研究的目的:
- 实现和演示一个新的几何布朗杆.
- 通过使用不对称障碍来研究分子的定向运输.
- 探索这个设备作为连续分子的潜力.
主要方法:
- 制造一个二维周期性阵列的不对称的障碍物从氧化在二氧化.
- 使用充电,光标记的脂在一个二维流体双层.
- 应用电场来驱动脂通过不对称的屏障阵列.
- 通过观察不对称障碍物对布朗运动的纠正,从而导致方向传输.
主要成果:
- 成功证明了脂分子的定向运输.
- 由于屏障的几何不对称性,观察到布朗运动的纠正.
- 展示了基于电泳流动性和扩散系数的连续分子的原理.
结论:
- 一个几何布朗式杆已经成功实现.
- 这种新型装置提供了一种定向分子运输和分离的方法.
- 几何子对膜相关分子的混合物进行选具有前景.
相关概念视频
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A protein's shape is critical to its function. For example, an enzyme can...
A protein's shape is critical to its function. For example, an enzyme can...
Membrane Fluidity
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Mechanisms of Membrane-bending
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Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
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Newman Projections
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.
Conformations of Ethane and Propane
In an organic molecule, free rotation about the carbon-carbon single bond results in energetically different conformers of the molecule. Due to this rotation, called the internal rotation, ethane has two major conformations — staggered and eclipsed.
Staggered conformation is a low energy and more stable conformation with the C-H bonds on the front carbon placed at 60°dihedral angles relative to the C-H bonds on the back carbon, leading to a reduced torsional strain. In staggered ethane, the...
Staggered conformation is a low energy and more stable conformation with the C-H bonds on the front carbon placed at 60°dihedral angles relative to the C-H bonds on the back carbon, leading to a reduced torsional strain. In staggered ethane, the...
¹H NMR: Complex Splitting
A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.

