增加的脂蛋白 (a) 是儿童静脉血栓栓塞的重要危险因素
U Nowak-Göttl1, R Junker, M Hartmeier
1Department of Pediatrics, Laboratory Medicine, Westfälische Wilhelms-Universität, Münster, Germany.
Circulation
|August 18, 1999
概括
升高的脂蛋白 (a) [Lp (a) ]水平是儿童静脉血栓栓塞的重要危险因素. 测量Lp (a) 对于查儿童出现这些事件至关重要.
科学领域:
- 心血管遗传学 心血管遗传学
- 儿科血栓形成症 儿童血栓形成症
- 脂质代谢 脂质代谢是什么
背景情况:
- 脂蛋白 (a) [Lp (a) ]水平是基因决定的,与动脉样硬化疾病有关.
- 在静脉血栓栓塞性疾病中Lp (a) 的作用,特别是在儿童中,还没有得到很好的描述.
- 已确定的血栓性风险因素包括调节血液凝固和纤维素分解的蛋白质.
研究的目的:
- 调查Lp (a) 作为儿童静脉血栓塞栓性疾病的危险因素的作用.
- 评估Lp(a) 和其他血栓性因素对静脉血栓形成风险的综合影响.
- 确定阿波利波蛋白[阿波利波蛋白]异型体型大小和Lp[阿波利波蛋白]水平/血栓栓塞的风险之间的关系.
主要方法:
- 测量了血清Lp(a),脂质,蛋白C,蛋白S和抗血水平.
- 分析了Apo(a) 异构体大小和因子V:Q(506) 突变的存在.
- 研究了186名静脉血栓症儿童和186名匹配的对照 (新生儿至18岁).
主要成果:
- 患有静脉血栓症的儿童的中位Lp (a) 水平显著更高 (19与4.4 mg/dL相比).
- Lp (a) 含量超过30 mg/dL,导致血栓栓塞事件的风险增加7.2倍.
- 因子V:Q506) 突变,蛋白C和抗血缺乏是独立的危险因素;高Lp50a与这些相结合,进一步增加了风险.
结论:
- 血清Lp (a) >30 mg/dL是儿童静脉血栓栓塞的重要危险因素.
- 应将Lp (a) 测量纳入儿科静脉血栓栓塞事件的病因查.
- Apo(a) 异构体大小与Lp(a) 水平和血栓栓塞的风险相反相关.
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