氨酸和物质P可以逆转由先天性心脏手术引起的肺内皮功能障碍
I Schulze-Neick1, D J Penny, M L Rigby
1Department of Paediatrics, Royal Brompton and Harefield NHS Trust, National Heart and Lung Institute (Imperial College of Science, Technology and Medicine), London, UK.
Circulation
|August 18, 1999
概括
接受心脏手术的儿童由于内皮功能障碍导致肺血管抵抗增加. 手术后补充L-氨酸和物质P可以恢复正常功能,建议新的治疗策略.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 肺高血压是什么意思 肺高血压
- 内皮细胞功能 内皮细胞功能
背景情况:
- 肺血管阻力 (PVR) 在心肺旁路术后的儿童中增加,与肺内皮功能障碍 (PED) 相关.
- L-氨酸-氧化 (NO) 途径对于调节血管度至关重要.
研究的目的:
- 在开放心脏手术之前和之后,对患有先天性心脏病的儿童进行PED调查.
- 评估L-氨酸-氧化物通路在心肺旁路后PVR中的作用.
主要方法:
- 评估了20名儿科患者 (手术前和术后).
- 在不同氧气水平和干预期间测量的PVR:L-arginine (L-Arg),物质P (Sub-P) 和吸入的氧化 (NO).
- 使用心脏导管,质谱和Fick方法.
主要成果:
- 在手术前的患者显示PED最小.
- 手术后的患者表现出更高的PVR,这表明PED显著.
- 术后患者的PVR通过L-Arg和Sub-P的管理得到改善.
结论:
- 手术后PVR增加表明心脏手术后儿童的PED可逆.
- 氨酸和物质P显示出作为治疗PVR的治疗剂的潜力.
- 在这种情况下,吸入NO并没有提供额外的好处.
相关概念视频
01:26Pneumothorax-I
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
01:27Pneumothorax-II
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations: