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快速感染口腔粘膜相关的淋巴组织与猿类免疫缺陷病毒

C Stahl-Hennig¹, R M Steinman, K Tenner-Racz

¹German Primate Center, 37077 Göttingen, Germany.

Science (New York, N.Y.)

|August 24, 1999

概括

的类似免疫缺陷病毒感染始于桃体,迅速扩散到淋巴组织. 该病毒向桃体密室附近的CD4+T细胞,而不是上皮.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
灵长类动物学灵长类动物学

背景情况:

粘膜相关的淋巴组织 (MALT) 在初始免疫反应中起着至关重要的作用.
了解早期病毒传播是开发免疫缺陷病毒感染有效干预措施的关键.

研究的目的:

调查猿免疫缺陷病毒 (SIV) 感染的初始事件和传播模式.
在相关动物模型中识别早期SIV复制的主要点细胞和解剖部位.

主要方法:

致病性SIV在子桃体上的创伤性应用.
病毒学测试和现场杂交以追踪病毒传播和识别感染细胞.
免疫组织化学分析以鉴定受感染细胞群的特征 (例如CD4+ T细胞).

主要成果:

在桃体中局部发起的SIV感染是关键的MALT.
迅速的全身传播到其他淋巴组织发生在几天内.
感染主要观察到CD4+桃体T细胞,特别是在桃体密室表皮附近.
在最初的应用部位 (状上皮质) 中没有检测到病毒复制.

结论:

桃体T细胞是SIV感染的早期目标.
桃体密室的专门表皮可能有助于病毒的运输和传播.
粘膜淋巴组织是免疫缺陷病毒感染的发病和早期传播的关键地点.

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