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很久以前学习的地方的记忆在海马体损伤后是完整的
1Veterans Affairs Medical Center, San Diego, California 92161, USA.
Nature
|August 24, 1999
概括
海马对于形成新的长期记忆至关重要. 患者E.P. 患者 患有海马损伤的人可以回忆旧的空间信息,但不能回忆最近的环境,挑战海马.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经生物学 神经生物学 神经生物学
背景情况:
- 位于中间叶内的海马体被广泛认为对记忆形成和检索至关重要.
- 一个著名的理论认为,海马可以构建和存储空间地图,这对于记住位置至关重要.
研究的目的:
- 调查海马和中间叶结构在提取非常遥远的空间记忆中的作用.
- 为了测试假设,这些结构对于形成长期声明性记忆至关重要,但对于回忆非常古老的记忆而言却不可或缺.
主要方法:
- 评估患者的空间回忆能力 (E.P.) 与广泛的双边海马和中间叶损伤.
- 在E.P.E. 被要求描述他童年时代的社区的空间布局,这是一个他已经50多年没有居住的地方.
- 进行比较的E.P. "的表现与来自同一地区的年龄相匹配的对照进行了比较,并测试了他对当前近期社区的了解.
主要成果:
- 在E.P.E. 证明他完整地回忆起他遥远的童年社区的空间布局,表现与对照组相当或比对照组更好.
- 相反地,E.P.也是一样的. 缺乏对他当前邻居的了解,他在失忆症发作后搬进了这个邻居.
结论:
- 中间叶不是空间地图的永久存储位置.
- 海马和相邻的中间叶结构对于长期声明性记忆 (空间和非空间) 的形成至关重要.
- 这些结构不需要检索非常遥远的记忆.
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