冠状病毒肺炎感染和早期无症状的动脉动脉样硬化
H S Markus1, M Sitzer, D Carrington
1Department of Clinical Neuroscience, King's College School of Medicine,Institute of Psychiatry, London, UK. h.markus@iop.kcl.uk
Circulation
|August 24, 1999
概括
这项研究发现,克拉米迪亚肺炎感染和早期动脉样硬化标志物 (如内心介质厚度) 之间没有联系. 需要进一步的研究来探索与更先进的动脉疾病的潜在关联.
科学领域:
- 心血管研究研究心血管研究
- 传染性疾病 传染性疾病
- 医学诊断 医学诊断 医学诊断
背景情况:
- 慢性克拉米迪亚肺炎感染被怀疑是动脉样硬化发展的原因.
- 肺炎菌在早期动脉样硬化中的作用尚不清楚.
- 动脉内心介质厚度 (IMT) 和斑块评估提供了早期动脉样硬化的见解.
研究的目的:
- 调查克拉米迪亚肺炎感染和早期动脉样硬化之间的关联.
- 为了确定C. pneumoniae的血清阳性是否与动脉IMT或斑块存在相关.
主要方法:
- 超声波成像测量了983名 (30-70岁) 个体的动脉IMT和斑块厚度.
- 测量了克拉米迪亚肺炎IgA和IgG抗体标位.
- 分析了血清阳性和动脉测量之间的关联,并根据风险因素进行调整.
主要成果:
- 在C. pneumoniaeIgA或IgG血清阳性和心动脉内膜介质厚度或斑块存在之间没有发现显著的关联.
- 观察到IgA血清阳性与大于50%的动脉狭窄之间存在潜在的关联,但在调整心血管风险因素后失去了意义.
- 在C. pneumoniae血清阳性和炎症标志物 (纤维素,C反应蛋白,白细胞计数) 之间没有发现相关性.
结论:
- 肺炎感染的血清学证据与早期动脉样硬化不相关.
- 与晚期动脉样硬化的可能联系需要在相关人群中进行进一步的研究.
- 肺炎感染似乎不会引起慢性系统性炎症状态.
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