神经免疫性尾炎是一种疾病
P Di Sebastiano1, T Fink, F F di Mola
1Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Switzerland.
Lancet (London, England)
|August 28, 1999
概括
涉及物质P (SP) 和血管活性肠 (VIP) 神经的神经扩散可能会导致非炎症尾的腹痛. 这表明一种名为神经免疫尾炎的独特疾病.
科学领域:
- 胃肠病学 胃肠病学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 15-25%的手术切除的尾没有表现出组织学性炎症,尽管怀疑尾炎.
- 在这些情况下,疼痛的病因仍然不清楚.
- 在慢性炎症中观察到神经的变化,这促使对类内化变化的调查.
研究的目的:
- 调查尾炎中P物质 (SP),血管活性肠 (VIP) 和生长相关蛋白-43 (GAP-43) 的体内化变化.
- 探索神经免疫相互作用在没有炎症的尾疼痛中的作用.
主要方法:
- 免疫细胞化学用于分析SP,VIP和GAP-43在31个附录样本 (16急性,15非急性) 和16个对照样本中.
- 数字化形态测量评估了SP免疫染色的密度.
- 样本被分为急性尾炎,非急性尾炎或正常.
主要成果:
- 与生长相关的蛋白-43 (GAP-43) 表达在非急性尾炎病例中升高.
- 与对照和急性尾炎相比,在非急性尾的粘膜层中发现了大量的SP和VIP免疫反应神经.
- 在SP/VIP神经和淋巴细胞之间观察到密切的空间关系,这些细胞位于淋巴毛囊的外部区域.
结论:
- 增加SP和VIP神经递质,以及附录中的神经扩散,在没有急性炎症的情况下,可能会导致右腹部疼痛.
- 这些发现表明"神经免疫尾炎"作为一个独特的病理实体.
- 这突显了尾病理中的神经和免疫系统之间的相互作用.
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