阿齐思罗米在控制气管瘤方面发挥了作用
J Schachter1, S K West, D Mabey
1Department of Laboratory Medicine, University of California, San Francisco 94143-0842, USA. jsch@itsa.ucsf.edu
Lancet (London, England)
|August 31, 1999
概括
与局部四环素相比,在整个社区口服的阿齐思罗密辛显著减少了克拉米迪亚虫感染和临床气管瘤. 这种口服阿齐思罗米治疗是一种有前途的策略,用于在特有地区控制气管瘤.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 气管瘤是全球可预防失明的主要原因之一.
- 目前的预防依赖于全社区的局部四环素治疗.
- 这项研究评估了口服阿齐思罗米作为瘤控制的替代品.
研究的目的:
- 为了比较社区范围内的口服阿齐思罗米辛与局部四环素在减少克拉米迪亚虫感染和临床气管瘤的疗效.
- 评估瘤流行地区的治疗遵从性和治疗结果.
主要方法:
- 在埃及,冈比亚和坦桑尼亚,匹配的村庄对被随机分配给接受口服阿齐思罗米或局部四环.
- 使用连接酶连锁反应 (LCR) 检测到了克拉米迪亚虫感染.
- 在基线和随访 (2-14个月) 时进行了临床检查和LCR测试.
主要成果:
- 与局部四环素相比,在1年的随访中,口服亚齐思罗米辛治疗导致全村LCR阳性和临床气管瘤活性显著减少.
- 在这两项干预中,治疗遵守率都超过了90%,但在埃及的一座四环环素村庄中略有例外.
- 与1年持续的LCR阳性相关的因素包括不接受阿兹罗密辛,年龄较小和基线LCR阳性.
结论:
- 社区范围内的口服亚齐思罗米显著减少了克拉米迪亚虫感染和临床瘤.
- 口服亚齐思罗米是一种潜在的重要和有效的方法,用于控制特有病区的气管瘤.
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