在表达单性的V1a受体的小鼠中增加了对静脉压素的附属反应
L J Young1, R Nilsen, K G Waymire
1Department of Psychiatry and Behavioural Sciences, Emory University, Atlanta, Georgia 30322, USA. lyoun03@emory.edu
Nature
|August 31, 1999
概括
氨酸血压素 (AVP) 通过V1a受体影响社会行为. 在V1a受体基因表达的差异解释了草原和山地之间的附属行为变化.
科学领域:
- 神经科学是一个神经科学.
- 行为内分泌学 行为内分泌学
- 进化生物学 进化生物学
背景情况:
- 氨酸血管压素 (AVP) 是一种关键的神经,可以调节脊椎动物的男性生殖和社会行为.
- 血管压素V1a受体 (V1aR) 在大脑中的分布在物种之间有很大差异,与社会结构相关.
- 了解V1aR表达差异的分子基础对于解释特定物种的社会行为至关重要.
研究的目的:
- 研究氨酸压缩素 (AVP) 和其V1a受体在不同飞物种中调解社会行为的作用.
- 探索物种特异性V1aR表达模式背后的分子机制.
- 为了确定大脑中的V1aR基因表达是否与社交行为有功能联系.
主要方法:
- 对草原 (社会性,一夫一妻制) 和山地 (非社会性,乱交) 进行氨酸血管压素 (AVP) 的中央管理.
- 对V1a受体基因的分子分析,包括促进体结构和潜在的基因重复.
- 携带草原 V1a受体基因的转基因小鼠的生成,以评估神经解剖学结合模式和行为反应.
主要成果:
- 中央AVP管理增加了草原小鸟的附属行为,但不是山地小鸟.
- 分子分析表明,草原V1aR基因中的基因重复或促进体结构变化有助于差异表达.
- 表达草原V1aR的转基因小鼠表现出与草原类似的V1aR结合模式,并在AVP注射后表现出增强的附属行为.
结论:
- 大脑中V1a受体基因表达的特定物种模式在功能上与男性社会行为的变化有关.
- 草原V1aR基因,可能是通过诸如重复之类的进化变化,在AVP对社交性的影响中存在差异.
- V1a受体神经解剖学和功能在脊椎动物的社会行为进化中发挥着关键作用.
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