在植入左心室辅助装置后,激活诱导的T细胞死亡和免疫功能障碍
H J Ankersmit1, S Tugulea, T Spanier
1Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Lancet (London, England)
|September 2, 1999
概括
左心室辅助装置 (LVAD) 植入会损害T细胞功能,增加感染风险. 接收LVAD的患者表现出细胞免疫力降低和更容易感染机会性感染,如疹.
科学领域:
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 医疗器械 医疗器械
背景情况:
- 心脏移植受到供体器官稀缺性的限制.
- 左心室辅助器件 (LVAD) 正在研究末期心力衰竭.
- 由于严重感染率高,LVADs面临着挑战.
研究的目的:
- 为了研究LVAD接受者的免疫反应.
- 为了检查与LVAD相关的感染和宿主免疫之间的关系.
主要方法:
- 在LVAD接受者 (n=40) 和对照者 (n=38) 中,比较候选感染率.
- 使用单克隆抗体和体内亡试验分析T细胞表型和功能.
- 在刺激后评估T细胞死亡,并使用统计分析对组进行比较.
主要成果:
- 接受LVAD的患者在3个月内患候选性感染的风险为28%,对照组为3% (p=0.003).
- 接受LVAD的患者表现出皮肤和T细胞增殖减少 (p<0.001).
- 在LVAD接受者中观察到T细胞亡的增加和CD4T细胞死亡的增加.
结论:
- 植入LVAD诱导异常的T细胞激活和细胞免疫缺陷.
- 接受LVAD的人对CD4 T细胞激活诱导的细胞死亡的敏感性增加.
- 在LVAD接受者的逐渐免疫缺陷增加了机会性感染的风险.
相关概念视频
Cell-mediated Immune Responses
Overview
Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy V: Interprofessional Care
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...


