尾部是霍克斯基因,它指定了最后端的多索菲尔分段
Nature
|September 7, 1999
概括
尾部 (caudal) 的本地盒子基因对成年果的后部发育至关重要,特别是分析. 它的缺席会导致转变,而子宫外表达会诱导分析形成,这表明它指定了末端的身体部分.
科学领域:
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
- 昆虫学 昆虫学是一门学科.
背景情况:
- 在Drosophila. homeobox基因尾部 (cad) 在胚胎前后轴形成和后部发育中起作用.
- 它在成年人发育中的功能,特别是终端结构中的功能,是不太了解的.
研究的目的:
- 为了研究尾部 (cad) 在成年Drosophila发育中的作用.
- 要确定cad是否作为指定最后端段的Hox基因而起作用.
主要方法:
- 在Drosophila中对CAD功能丧失和子宫外表达突变的遗传分析.
- 调查CAD与刺 (Hh) 信号通路之间的相互作用.
- 分析基因表达模式,包括距离不大,胸膜,甚至跳过.
主要成果:
- 成年的CAD功能丧失导致的转化为男性生殖器.
- 在头部或翅膀中CAD的异胎表达可以诱导异胎分析的发展.
- CAD与子路径一起作用,通过Distal-less指定外部分析.
- 在没有Hh通路的情况下,cad促进了内部分析的发展,可能通过brachyenteron和甚至跳过.
结论:
- 尾部 (cad) 对于成年Drosophila analia的正常发育至关重要.
- 卡德作为Hox基因起作用,指定了的末端后部段.
- 卡德与刺路径相互作用,以模拟分析结构,区分外部和内部命运.
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