实验性病毒性心肌炎的治疗与介白素-10的治疗
R Nishio1, A Matsumori, T Shioi
1Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Circulation
|September 8, 1999
概括
在病毒性心肌炎的小鼠模型中,INTERLEUKIN (IL) - 10治疗显著改善了生存率. 这种细胞因子治疗减少了心脏炎症和iNOS mRNA表达,这表明IL-10在病毒性心脏感染中具有治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 心脏病学 心脏病学
背景情况:
- 互乐金 (IL) - 10是一种具有已知的免疫调节作用的细胞因子.
- IL-10对病毒性心肌炎的特定影响尚未完全阐明.
研究的目的:
- 在急性病毒性心肌炎的小鼠模型中研究复合人类IL-10 (rhIL-10) 的治疗效果.
- 评估rhil-10对生存,心脏病理,细胞因子概况和病毒载荷的影响.
主要方法:
- 在DBA/2小鼠中,使用脑肌心炎病毒 (EMCV) 诱导了急性病毒性心肌炎.
- 小鼠每天接受rhIL-10注射或载体控制,从第0天开始.
- 分析了生存率,心肌组织病理,心脏细胞因子水平 (ELISA),病毒RNA和可诱导的氧化合成酶 (iNOS) mRNA表达.
主要成果:
- rhIL-10治疗显著增加了14天生存率 (80%对照组为30%).
- 心脏病变减弱,瘤亡因子-α和IL-2的水平被rhIL-10抑制.
- rhIL-10显著降低了心肌iNOS mRNA表达,但没有影响病毒度.
结论:
- rhIL-10在病毒性心肌炎的小鼠模型中显示出显著的治疗疗效.
- 通过调节炎症反应,包括iNOS表达,IL-10可能会发挥其有益作用.
- 这些发现支持IL-10作为治疗病毒性心肌炎的潜力.
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