在男性吸烟者中,酒精消耗和中风发病率
J M Leppälä1, M Paunio, J Virtamo
1Department of Public Health, University of Helsinki, Finland. jaana.leppala@helsinki.fi
Circulation
|September 14, 1999
概括
过度饮酒会增加中风的风险,尤其是脑下关节下出血. 适度饮酒也可能增加某些类型中风的风险. 血压和高密度胆固醇似乎影响了这些与酒精有关的中风风险.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 酒精消费与中风亚型的关系尚未完全理解.
- 像血压和HDL胆固醇这样的机制调解酒精对心脏病的影响,但对于脑血管疾病来说并不清楚.
研究的目的:
- 研究酒精消费与男性吸烟者中不同类型中风亚型风险之间的剂量反应关系.
- 探索系统血压和高密度胆固醇在酒精对中风发生率的影响中介作用.
主要方法:
- 一项对26556名50-69岁的男性吸烟者的队列研究,他们以前没有中风.
- 参与者按酒精摄入量进行分类:不饮酒者,轻量饮酒者 (每天24克),中度饮酒者 (每天25-60克) 和重量饮酒者 (每天60克以上).
- 计算了中风亚型 (下关节出血,脑内出血,脑梗塞) 的调整相对风险.
主要成果:
- 过度饮酒与子arachnoid出血 (RR 1.6) 和脑梗塞 (RR 1.5) 的风险增加有关.
- 适度饮酒显示,下大脑关节出血 (RR 1.3) 和脑梗塞 (RR 1.2) 的风险更高.
- 系统性血压减弱了酒精对所有中风亚型的影响,而高密度胆固醇则根据中风类型产生了不同的影响.
结论:
- 对于中风亚型,酒精消费表现出不同的剂量反应模式:线性用于下关节出血,U形用于脑内出血,J形用于脑梗塞.
- 系统性血压和高密度胆固醇似乎调解了酒精对中风的影响,这表明了其他潜在机制.
- 需要进一步的研究来充分阐明这些关系.
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