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通过饮食降低脂质可以降低子动脉瘤中的组织因子表达

M Aikawa¹, S J Voglic, S Sugiyama

¹Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. 02115, USA. maikawa@bics.bwh.harvard.edu

|September 14, 1999

概括

降低脂质通过降低动脉样硬化中的组织因子 (TF) 表达和活性来降低血栓并发症. 这项研究研究了子模型中这种效应背后的机制.

科学领域:

心血管研究研究心血管研究
动脉样硬化病理生理病理学
血栓形成机制血栓形成机制

背景情况:

精确的降脂疗法减少冠状动脉样硬化中血栓性并发症的机制尚未完全理解.
在动脉瘤中组织因子 (TF) 的过度表达可能会在斑块破坏后促进血栓形成.
已知CD40连接体 (CD40L) 在体外增强TF表达.

研究的目的:

在动脉样硬化的实验模型中,研究降脂是否会降低TF表达和活性.
为了探索脂质降低,TF,CD40L和神经动脉瘤中的CD40之间的关系.

主要方法:

动脉瘤是通过气球损伤和胆固醇食诱导子的大动脉.
通过切换到饮食来实现脂质降低.
使用免疫定位和图像分析量化了TF,CD40L和CD40的表达和定位.
使用染色体检测和RT-PCR评估了TF活性和mRNA水平.

主要成果:

在动脉瘤巨细胞,光滑肌细胞和内皮细胞中,TF的表达很高,与CD40L和CD40共聚.
降低脂质显著降低了TF蛋白和mRNA表达,以及CD40L和CD40.
在脂质降低后,TF与因子VIIa和X的局部结合下降,表明TF活性降低.

结论:

这些发现表明,减少组织因子 (TF) 的表达和活性代表了一种新的机制,通过这种机制,降低脂质可以减轻动脉样硬化中的血栓性并发症.
向TF可能提供一种治疗策略,以预防动脉血事件.

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