Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

[A case of subacute phosphate nephropathy caused by oral sodium phosphate].

Zhonghua nei ke za zhi·2024
Same author

[Epidemic characteristics of mycoplasma pneumoniae infection and drug-resistant gene mutations in hospitalized children aged 0-17 in Ningbo City from 2019 to 2023].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2024
Same author

[Analysis on early predictors of respiratory depression in patients with glufosinate poisoning].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2024
Same author

[Progress in IgA-dominant infection-related glomerulonephritis].

Zhonghua nei ke za zhi·2023
Same author

[Clinical significance of intersphincteric resection related anatomy effect on surgical safety].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2023
Same author

Moisture retention of glycerin solutions with various concentrations: a comparative study.

Scientific reports·2022

相关实验视频

Updated: Jul 16, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

广泛查测试用于脂储存疾病.

C S Chen1, M C Patterson, C L Wheatley

  • 1Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, MN 55905-0001, USA.

Lancet (London, England)
|September 18, 1999
PubMed
概括

一种新的光脂质检测方法通过检测异常的溶酶体积累,有效地选各种脂质储存疾病. 这种方法显示出高精度和潜在的药物查来治疗这些衰弱的条件.

科学领域:

  • 生物化学 生物化学
  • 细胞生物学 细胞生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 脂质储存疾病导致显著的发病率和死亡率,呈现出各种神经和发育症状.
  • 目前的诊断方法缺乏对这些复杂疾病的普遍初始查试验.

研究的目的:

  • 开发和验证一种新的光检测方法,用于初始查脂质储存疾病.
  • 研究BODIPY-LacCer在识别细胞脂质积累模式方面的实用性.

主要方法:

  • 使用的N-[5-]5,7-二甲基博隆二甲二化物) -1-坦]D-乳糖氨酸 (BODIPY-LacCer),是一种光乳糖胺类似物.
  • 通过监测光发射变化,检查活细胞中的细胞内脂质分布.
  • 进行了脉冲追踪实验和使用患者衍生纤维细胞的蒙面研究.

主要成果:

  • BODIPY-LacCer在患有多种类型的脂质储存疾病的患者的纤维细胞的溶酶体中积聚.
  • 在对照细胞中,光脂质主要留在戈尔吉综合体中.
  • 该试验显示出高诊断准确性,具有96.2%的灵敏度和90.0%的特异性,用于识别疾病和控制细胞系.

结论:

更多相关视频

Advancing Dyslexia Assessment in Children Through Computerized Testing
09:00

Advancing Dyslexia Assessment in Children Through Computerized Testing

Published on: August 16, 2024

Prion Safety Laboratory Swipe Test
06:01

Prion Safety Laboratory Swipe Test

Published on: February 14, 2025

相关实验视频

Last Updated: Jul 16, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Advancing Dyslexia Assessment in Children Through Computerized Testing
09:00

Advancing Dyslexia Assessment in Children Through Computerized Testing

Published on: August 16, 2024

Prion Safety Laboratory Swipe Test
06:01

Prion Safety Laboratory Swipe Test

Published on: February 14, 2025

  • BODIPY-LacCer试验显示出作为脂质储存疾病的初始一般查工具的希望.
  • 这种方法可以适应自动化,大规模的药物查,以准 lysosomal 存储.
  • 观察到的共同积累模式表明,在不同的脂质储存障碍中,共享的细胞功能障碍机制.