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Updated: May 5, 2026

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
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SOCS1 缺乏导致淋巴细胞依赖的围产期死亡率

J C Marine1, D J Topham, C McKay

  • 1Howard Hughes Medical Institute, and Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Cell
|September 18, 1999
PubMed
概括

抑制细胞因子信号传递1 (SOCS1) 缺乏导致小鼠因免疫系统失调而过早死亡. 消除干扰素 (IFNγ) 或RAG2可以防止这种致命性,突出显示淋巴细胞.

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