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单个单位的同情性放出:人类高血压疾病的定量评估
J P Greenwood1, J B Stoker, D A Mary
1Department of Cardiology, The University of Leeds (UK). john_greenwood@hotmail.com
Circulation
|September 24, 1999
概括
在高血压中,交感神经活动升高. 测量单个血管缩单位 (s-MSNA) 显示,与严重阶段相比,早期高血压的交感输出增加.
科学领域:
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
- 高血压研究 高血压研究
背景情况:
- 在使用微神经图的高血压中存在不一致的关于同情性过活性的报道.
- 之前的研究依赖于多单元放电 (MSNA爆发),可能会掩盖交感输出的更细微细节.
- 调查单个血管缩单元 (s-MSNA) 提供了一种更精确的方法来评估同情活动.
研究的目的:
- 通过分析单个血管缩单元 (s-MSNA) 来描述高血压疾病中的同情输出.
- 为了比较从单个单位与多单位爆发的同情活动测量.
- 研究基本高血压不同阶段的同情活动的差异.
主要方法:
- 对74名受试者进行了血液压力范围的检查:正常 (NT),高正常 (HN) 和基本高血压阶段1-3 (EHT-1,EHT-2/3).
- 使用多单元爆发 (MSNA) 和单单元血管缩脉冲 (s-MSNA) 测量了外周交感活动.
- 相关的s-MSNA和MSNA发现和分析的变异性.
主要成果:
- 在s-MSNA和MSNA测量之间观察到显著的相关性.
- 无论是EHT-1/2/3和HN组,都比NT组显著增加了s-MSNA和MSNA (分别P<0.01和P<0.05).
- s-MSNA显示了与EHT-2/3 (P<0.05) 相比,EHT-1的同情输出显著更高,这与MSNA爆发没有明显差异.
结论:
- 对s-MSNA的量化提供了强有力的证据,证明本质性高血压中中枢交感输出增加.
- 这种单单元技术提供了新的见解,在较轻的/较早的高血压阶段,与更严重的疾病相比,表现出增强的同情输出.
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