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Updated: Jul 28, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
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一个NFAT抑制剂的亲和驱动的选择比环素A更有选择性

J Aramburu1, M B Yaffe, C López-Rodríguez

  • 1Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|September 25, 1999
PubMed
概括

一种新型的抑制剂选择性地阻断了氨酸-NFAT相互作用,防止T细胞激活和细胞因子基因表达. 这种有针对性的方法提供了比目前的药物更少的毒性治疗策略.

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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The heterodimer of NF-κB...