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局部脉压,平均血压和大动脉重塑之间的关联
P Boutouyrie1, C Bussy, P Lacolley
1Departments of Pharmacology, Broussais Hospital, and INSERM U337, Paris, France.
Circulation
|September 29, 1999
概括
局部脉压显著影响动脉重塑,导致扩大和加厚. 在辐射动脉中没有观察到这种效应,突出显示了对脉动机械负荷的特定反应.
科学领域:
- 心血管生理学心血管生理学
- 动脉生物力学 动脉生物力学
- 高血压研究 高血压研究
背景情况:
- 动脉重塑受血动力学力量的影响.
- 了解局部脉冲压和平均血压的作用至关重要.
- 弹性动脉和肌肉动脉之间的动脉重塑的差异尚未完全理解.
研究的目的:
- 调查局部脉冲压和平均血压对动脉重塑的独立影响.
- 为了比较中央弹性动脉 (常见动脉) 和外围肌肉动脉 (辐射动脉) 的这些效应.
主要方法:
- 非侵入性高清回声追踪,以测量亲密介质厚度和内部直径.
- 用于局部脉冲压力测量的平面度计.
- 在健康受试者和高血压患者中进行多变量回归分析.
主要成果:
- 动脉直径和壁厚在很大程度上取决于动脉脉压 (P<0.0001).
- 平均血压和臂脉压并没有独立地影响动脉重塑.
- 辐射动脉直径与年龄相关,而内心介质厚度与平均血压相关 (P<0.001),而不是辐射脉冲压.
结论:
- 局部脉冲压是动脉重塑的关键决定因素在弹性动脉,如常见的动脉.
- 肌肉动脉 (辐射动脉) 中的动脉重塑受到不同的影响,主要是平均血压的影响.
- 循环拉伸可能有助于脉冲压引起的弹性动脉重塑.
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