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摘取器官期间的损伤:来自英国国家移植数据库的数据. 腎臟諮詢小組 腎臟諮詢小組
S J Wigmore1, F M Seeney, H C Pleass
1Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, UK.
Lancet (London, England)
|October 8, 1999
概括
在器官采集期间损伤很常见,但很少影响移植存活率. 较年轻的捐赠者年龄和专门的取回小组改善了移植的结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植手术 移植手术
- 器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器
背景情况:
- 在器官采集过程中脏损伤是一个公认的,但潜在的报道不足的问题.
- 评估损伤的实际发生率及其对移植成功的影响至关重要.
研究的目的:
- 为了确定器官提取过程中脏损伤的真实速度.
- 评估这种损伤对移植存活率的影响.
主要方法:
- 英国国家移植数据库的分析记录了5年来死体脏捐赠的记录.
- 检索团队的分类 (肝脏与脏) 和损伤报告.
- 对1年和3年移植生存数据的多变量考克斯回归分析.
主要成果:
- 19%的提取脏报告有损伤;只有3%的脏被捐赠者和接受者中心报告.
- 损伤没有显著影响1年或3年移植存活率 (分别p=0.40和p=0.81).
- 捐赠者的年龄显著影响了移植存活率 (p<0.01),老年捐赠者的结果较差.
结论:
- 尽管提取时损伤的发生率很高,但大多数器官在不影响生存的情况下仍然适合移植.
- 在年轻的捐赠者中,损伤较少,并且当肝脏移植团队或大体积中心进行取回时,损伤较少.
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