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Updated: Aug 13, 2026

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition
06:02

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Published on: June 10, 2016

雌激素抑制了血管光滑肌肉细胞依赖的先发性纤维细胞迁移 in vitro

G Li1, Y F Chen, G L Greene

  • 1University of Alabama at Birmingham, Department of Medicine, Division of Transplantation, Chicago, ILL, USA.

Circulation
|October 12, 1999
PubMed
概括

雌激素通过抑制随机纤维细胞迁移来保护血管损伤. 这通过血管光滑肌细胞上的雌激素受体发生,揭示了一个新的血管保护机制.

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...