流感是一次流感
1Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. njc1@cdc.gov
Lancet (London, England)
|October 16, 1999
概括
新型流感疫苗和抗病毒药物为预防和治疗呼吸系统疾病提供了新的希望. 这些进展,包括活体减弱疫苗和神经氨基酶抑制剂,有望改善流感控制和临床实践.
科学领域:
- 病毒学和免疫学 病毒学和免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 流感仍然是所有年龄组急性呼吸道疾病的重要原因.
- 目前的流感预防严重依赖于非活化疫苗,主要针对高风险人群.
- 持续的流感负担需要探索创新的控制策略.
研究的目的:
- 审查最近在流感预防和控制方面的进展.
- 突出新型流感疫苗和抗病毒疗法的发展.
- 讨论这些进展对临床实践和公共卫生的潜在影响.
主要方法:
- 一种实验性活体,减弱,鼻内注射的三价流感疫苗的评估.
- 临床试验评估针对神经aminidase分子的新抗病毒药物.
- 审查快速诊断试验的流感的发展.
主要成果:
- 鼻入活体减弱型流感疫苗在幼儿中对A型流感 (H3N2) 和B型流感有很高的疗效.
- 新的神经氨基酶抑制剂抗病毒药物在临床试验中证明对A型和B型流感病毒有效.
- 由于新抗病毒药物的预期使用,快速诊断测试的发展正在加速.
结论:
- 最近的科学突破为流感管理提供了有希望的新工具.
- 新疫苗,抗病毒药物和诊断测试的整合预计将改变流感控制策略.
- 这些进展可能会对临床实践和患者的治疗结果产生重大影响.
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