3-O-硫酸硫酸在简单疹病毒中的新型作用 1条目
1Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Cell
|October 16, 1999
概括
简单疹病毒1型 (HSV-1) 进入细胞需要特殊的硫酸肝素修饰. 这些修改会为病毒葡萄糖蛋白D (gD) 创建结合点,从而启动病毒感染.
科学领域:
- 病毒学 病毒学
- 葡萄糖生物学 葡萄糖生物学
- 细胞生物学 细胞生物学
背景情况:
- 简单疹病毒1型 (HSV-1) 使用细胞表面硫酸肝素 (HS) 蛋白质糖因子通过gB和Gc糖蛋白进行初始附着.
- 病毒进入需要病毒包裹与宿主细胞膜的融合,这一过程与初始结合不同.
研究的目的:
- 调查特定的硫酸肝素修饰在促进HSV-1进入中的作用.
- 确定HS结构对病毒葡萄糖蛋白结合和随后的进入有所贡献的精确机制.
主要方法:
- 对病毒结合和进入具有不同肝硫酸盐结构的细胞的分析.
- 研究病毒葡萄糖蛋白 (gB,Gc和gD) 与修饰的肝素硫酸盐链的相互作用.
主要成果:
- 通过D-glucosaminyl 3-O-sulfotransferase异型修饰的特定的肝酸盐链,作为HSV-1糖蛋白D (gD) 的结合点.
- 在HS上,这些gD结合点对于启动HSV-1进入过程至关重要.
- 细胞对HSV-1感染的敏感性取决于HS的存在和特定的3-O-硫化模式.
结论:
- 肝素硫酸盐3-O-硫化是HSV-1细胞进入的关键决定因素.
- 在HS上存在由3-O-硫化生成的特定的gD结合位点,对于病毒感染至关重要.
- 细胞对HSV-1的敏感性是一个多因素过程,涉及HS的存在和特定的硫化模式.
更多相关视频
08:36The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials
Published on: April 19, 2024
11:43Procedures for the Identification of SARS-CoV-2 Entry Inhibitors as Potential Antivirals using MLV-Based Pseudoviruses
Published on: February 27, 2026
相关概念视频
01:29Subviral Agents
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
01:30Inhibitors of Viral Protein Synthesis
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
01:25Inhibitors Of Virion Release
Viral replication and dissemination rely on efficient mechanisms for host cell entry, genome replication, assembly, and release. Influenza viruses, such as types A and B, are negative-sense single-stranded RNA viruses with a segmented genome, that depend on two critical surface glycoproteins to carry out these processes: hemagglutinin (HA) and neuraminidase (NA). HA initiates infection by binding to sialic acid residues on the surface of host epithelial cells, facilitating receptor-mediated...
01:22Antiviral Nucleoside Inhibitors
Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...