相关实验视频

Updated: Jul 10, 2026

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
09:20

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

缺乏MT1-MMP的小鼠由于缺乏原蛋白的循环,会发展为矮体,骨质疏松症,关节炎和结合组织疾病

K Holmbeck1, P Bianco, J Caterina

  • 1MMP Unit, National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA.

Cell
|October 16, 1999
PubMed
概括

缺乏MT1-矩阵金属蛋白酶 (MT1-MMP) 的小鼠表现出骨和软组织缺陷,突出显示MT1-MMP.

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相关概念视频

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...