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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...

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相关实验视频

Updated: Jul 7, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
09:23

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

表观遗传学:通过抑制进行调节.

A P Wolffe1, M A Matzke

  • 1Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, MD 20892-5431, USA. awlme@helix.nih.gov

Science (New York, N.Y.)
|October 16, 1999
PubMed
概括
此摘要是机器生成的。

表观遗传学涉及遗传的基因表达变化,而不会改变DNA序列. 这些关键机制影响着发育,疾病和基因操纵,突出显示了它们的广泛相关性.

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Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants
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Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Published on: July 29, 2019

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe
13:22

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe

Published on: September 13, 2022

相关实验视频

Last Updated: Jul 7, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
09:23

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants
08:58

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Published on: July 29, 2019

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe
13:22

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe

Published on: September 13, 2022

科学领域:

  • 遗传学和分子生物学
  • 发展生物学 发展生物学
  • 医学科学 医学科学 医学科学

背景情况:

  • 表观遗传学研究了在没有改变DNA序列的情况下遗传的基因表达变化.
  • 表观遗传现象,如印记和转基因突变,挑战了孟德尔遗传.
  • 这些机制对于正常发育至关重要,但与癌症等疾病有关.

研究的目的:

  • 探索核酸序列同质性在表观遗传调节中的作用.
  • 了解表观遗传机制如何影响DNA甲基化,染色质重塑和RNA周转.
  • 检查表观遗传控制对发育,疾病和遗传操纵的影响.

主要方法:

  • 研究核酸序列识别与表观遗传向之间的联系.
  • 分析表观遗传机制对细胞过程的影响.
  • 审查表观遗传学在发育和疾病病理学的作用.

主要成果:

  • 核酸序列同质识别与表观遗传修饰有关.
  • 表观遗传机制保护细胞免受寄生元素的影响,但可以阻碍遗传操纵.
  • 在癌症和其他人类疾病中观察到表观遗传控制的失调.

结论:

  • 表观遗传过程是基因表达调节和发育的基础.
  • 了解表观遗传学对于推进医学和生物技术至关重要.
  • 表观遗传失调是人类疾病发病的一个重要因素.